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***Important Announcement on COVID-19***
CHITIN is contingency planning for impediments that trial delivery teams are experiencing as a result of COVID-19.
The CHITIN Programme Management Group is giving significant consideration to the breadth of our research activities and we are liaising with the Special EU Programmes Body. Some trials have paused or put on hold elements of their work to ensure participant and researcher health & safety is prioritised.
Some trial delivery staff are working remotely and discovering new ways of working to meet research deliverables as far as possible.

We thank the CHITIN Project network for their continued dedication and commitment to the programme and we are here to support you.


A randomised pilot study of a theory-based intervention to improve appropriate polypharmacy in older people in primary care (PolyPrime) (Host Organisation – QUB)

Polypharmacy (the use of multiple medicines) is considered to be a major prescribing challenge.  This three-phase pilot study will seek to improve prescribing of appropriate polypharmacy in older people living in their own homes. 

In Phase 1, we will interview 24 General Practitioners (GPs) across 12 practices in the Republic of Ireland (ROI) border counties and use the findings to refine the intervention package (consisting of a video and a patient recall system and which was developed in Northern Ireland). 

In Phase 2, we will undertake a randomised pilot study involving 12 GP practices. Practices will be randomised to intervention (n=6) or control groups (n=6), whereby the intervention package will be tested in the intervention practices and usual care will continue in the control practices. Eligible patients will be invited to attend an appointment (at baseline and six months) with their GP, during which their medication will be reviewed and polypharmacy addressed. 

In Phase 3, a mixed methods process evaluation will be conducted to inform interpretation of findings. 

The potential benefits from this health research include a refined intervention and an understanding of its implementation and expanded capacity to undertake research in the defined area through training and mentoring.

Lead Contact:

Professor Carmel Hughes, Queen’s University Belfast

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